Tuberculosis drug may work better than others in its class

Treatment of tuberculosis involves a combination of several drugs, sometimes including drugs from a class known as fluoroquinolones. Using computer simulations, scientists have shown that the fluoroquinolone known as moxifloxacin may be superior to two other commonly used fluoroquinolones, according to a new paper in PLOS Computational Biology.
Tuberculosis infects millions of people every year and requires at least 6 months of treatment with multiple drugs. This treatment can include one of three fluoroquinolones: moxifloxacin (MOXI), levofloxacin (LEVO), or gatifloxacin (GATI). However, existing data from clinical trials and animal studies are inadequate to determine which is best or if all three are equivalent.
In the new study, ElsjePienaar and colleagues at the University of Michigan in Ann Arbor and Rutgers developed a computer model to simulate the effects of the three drugs on granulomas -- clusters of host cells and bacteria that develop in the lungs of tuberculosis patients. The computer model incorporates experimental data on the three drugs, as well as extensive knowledge on the chemistry of their activity.
Source :      2017/8/31 08:57

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