Prediciting TB's behavior

Genetic drug resistance tests as good in gauging treatment outcome, death risk as traditional culture-based tests

Novel molecular tests are gaining popularity as a rapid way to detect genetic mutations that render tuberculosis impervious to drugs. Yet, how well these new tests fare in gauging risk of actual drug failure and patient death has remained unclear.
Now research led by scientists at Harvard Medical School reveals that when it comes to predicting response to treatment and risk of dying, molecular tests that detect resistance to a class of TB drugs known as fluoroquinolones may be as good and even superior to traditional drug-sensitivity tests conducted in lab cultures.
The findings of the research are published Aug. 3 in Clinical Infectious Diseases.
To eliminate the chance that factors other than the type of test being used would influence the results, the researchers also analyzed individual patient treatment regimens, disease severity, the presence of other diseases, smoking and nutritional status, and previous TB treatment, among other characteristics.
Source :      2017/8/20 12:34

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