New report says completing a course of antibiotics even after symptoms abate is overrated

Antibiotics are a boon to mankind and as more and more microorganisms are developing a resistance to these drugs, researchers are delving deeper into the mechanisms of this resistance. It is a commonly held view that once begun, a course of antibiotics should be completed to prevent the emergence of resistance among the microbes.
Now Scientists have come up with a new analysis that differs from this “commonly held” notion. They find that there is no connection between exposure to antibiotics and development of antibiotic resistance in large populations as well as in individual patients. Thus, unnecessary antibiotic use should be curbed to prevent resistance. Their analysis is published in the British Medical Journal.
Scientists have explained the mechanism of development of antibiotic resistance:
Target selected resistance - When a microbe multiplies within the host it leads to infection. These microbes may undergo genetic mutations that may make them deadlier and resistant to antibiotics. These genetic mutations are seen to be accelerated in case of inadequate dosing of the antibiotics or when a single drug is used to kill the microbe. Tuberculosis, HIV, typhoid, malaria and gonorrhoea are notable infections that develop resistance in this manner.
Collateral selection – There are several bacteria types that live harmlessly within the gut or other mucus membranes. During antibiotic treatment for other infections, these harmless bacteria genetically mutate to become resistant and cause infections. Their mutations are passed on to other strains of the bacteria leading to antibiotic resistance. Organisms that show this type of resistance include Methicillin Resistant Staph aureus (MRSA).
Source : www.news-medical.net      2017/8/20 10:09

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