Bacteria from cystic fibrosis patient could help thwart antibiotic-resistant TB

The number of drug-resistant tuberculosis (TB) cases is rising globally. But a newly discovered natural antibiotic -- produced by bacteria from the lung infection in a cystic fibrosis patient -- could help fight these infections. Lab testing reported in the Journal of the American Chemical Society shows that the compound is active against multi-drug resistant strains.
The researchers discovered that one species, Burkholderia gladioli, which was isolated from the sputum of a child with cystic fibrosis, produces an antibiotic called gladiolin. The compound belongs to the same structural class as etnangien, another antibiotic that has been investigated for its ability to jam bacterial cell machinery. But etnangien is highly unstable. The researchers found that gladiolin is much more stable than etnangien, and could therefore potentially be a better drug candidate. Lab testing also showed that gladiolin blocked the growth of four drug-resistant TB strains.
Source : www.sciencedaily.com      2017/7/11 10:35

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