Biological fingerprint of tuberculosis meningitis discovered in children

Children with tuberculosis meningitis -- a brain and spinal cord infection that leads to disability and death -- have a biological fingerprint that can be used to assess the severity of the condition, help decide the best course of treatment, and provide clues for novel treatments, scientists at the Francis Crick Institute, Imperial College London and the University of Cape Town reveal.
By comparing the blood and spinal cord fluid of 44 children with tuberculosis meningitis (TBM) and 20 patients with other spinal cord disorders, the team identified a set of biological markers elevated in TBM. The most common markers indicate damage of neurons and neuron-supporting cells, and their presence in the bloodstream and spinal cord can help to determine disease progression. The research, funded by Wellcome, is published in the journal of Clinical Infectious Diseases.
Source : www.sciencedaily.com      2017/7/11 10:17

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