Microbiology: Many forks make light work

New insights into the control of DNA replication and cell division in Corynebacterium glutamicum, a biotechnologically important microorganism, could help to optimize the industrial production of amino acids.
In comparison with bacteria like Escherichia coli, corynebacterial cultures grow relatively slowly. Microbiologist Professor Marc Bramkamp from Ludwig-Maximilians-Universitaet (LMU) in Munich and his research team have taken a closer look at C. glutamicum's mode of growth and proliferation, and uncovered previously unknown aspects of these processes, which can be exploited to enhance its growth rate.
C. glutamicum is closely related to a number of clinically significant pathogens, including the species responsible for infectious diseases such as diphtheria, tuberculosis or leprosy. "Since fundamental cell biological processes in closely related organisms are very often similarly structured, our findings should allow us to make reliable predictions in relation to the growth modes of these pathogens," Bramkamp points out. He and his colleagues believe that their results will also facilitate efforts to develop new treatments for corynebacterial infections, based on the inhibition of DNA replication.
Source : www.sciencedaily.com      2017/7/5 11:29

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