New mechanism of tuberculosis infection

A new study identifies an alternative route of entry that could have significant implications for the development of new therapies to prevent tuberculosis infection. The research team found that microfold cell (M-cell) translocation is a new and previously unknown mechanism by which Mycobacterium tuberculosis (Mtb) enters the body. M-cells are specialized epithelial cells that transport particles from the airway or mucosal surface to the compartment below the cell. The study shows that once Mtb bacteria are inhaled, they can enter the body directly through M-cells that line the airway tissue, and then travel to the lymph nodes and beyond. This is a key finding that suggests disease onset outside of alveolar macrophages is not only possible, but also important in the pathogenesis of tuberculosis infection.
Source :      2016/8/11 09:22

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