Slight change to antibacterial drug may improve TB treatments

Researchers with Vanderbilt University have discovered that one small chemical change to an existing antibacterial drug results in a compound that is more effective against its target enzyme in tuberculosis.Not only does the new compound -- a derivative of the fluoroquinolonemoxifloxacin -- work better against the wild-type tuberculosis enzyme, it maintains activity against resistant forms of the enzyme.Changing moxifloxacin at the critical position resulted in a compound (8-methyl moxifloxacin) that was more potent against the wild-type gyrase. The new compound was also effective against gyrase containing clinically relevant resistance mutations -- even more effective than moxifloxacin itself was against the wild-type gyrase.The hope is that the modified moxifloxacin will be an effective drug that results in a better treatment for tuberculosis.
Source :      2016/3/6 08:42

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