Expanded drug regimens associated with better treatment response in multidrug-resistant tuberculosis

Treating multidrug-resistant tuberculosis (MDR TB) with regimens that include a greater number of drugs may improve outcomes, and baseline drug susceptibility testing (DST) could identify drugs with the greatest likelihood of success, according to a paper published this week in PLOS Medicine. The prospective cohort study used information on regimen composition, baseline DST, and time to sputum conversion from 1,137 adults with MDR TB, from nine countries. The researchers found that receiving an average of at least six potentially effective drugs per day was associated with a 36% greater likelihood of responding to treatment than receiving an average of at least five but fewer than six potentially effective drugs per day, which is recommended by World Health Organization (WHO). The results suggest changes to the current WHO guidelines for the treatment of MDR TB might be beneficial.
Source : www.medicalnewstoday.com      2016/1/5 10:33

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