Study reveals structure of tuberculosis enzyme, could offer drug target

A team of scientists have determined the structures of several important tuberculosis enzymes, which could lead to new drugs for the disease. Researchers have been interested in the mycobacterium IMPDH enzyme, a part of a cellular process that controls the making of guanine nucleotides, as a drug target for years, but haven’t been able to produce it well enough to study it. In the new study, researchers engineered this enzyme to a new version, which its functions is very similarly to the original, but is much easier to purify and crystallize for study. 
Source : www.anl.gov      2015/11/15 10:30

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