Screening optimization of latent Tuberculosis infection in rheumatoid arthritis patients.

Rheumatoid arthritis (RA) patients are at increased risk of latent tuberculosis infection (LTBI) but there are no clear guidelines for LTBI screening with Tuberculin Skin Test (TST) or Quantiferon TB Gold testing (QFT-G). So, a retrospective study was conducted to evaluation the RA patients who had both TST and QFT-G testing. By analyzing data, low-moderate agreement between TST and QFT-G was appeared. In the absence of clearly defined gold standard and limitations associated with both tests, researchers propose early screening with both tests for patients who need prompt treatment with BRMs. Patients who are not immediate candidates for BRM treatment may be safely and cost effectively screened with a two-step process: initial screening with TST and if negative, IGRA testing. Also, patients positive for either test should be promptly treated.

Source :      2015/8/29 09:54

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