CD3 ICOS T cells show differences in the synthesis of nitric oxide, IFN-γ, and IL-10 in patients with pulmonary tuberculosis or in healthy household contacts

Evidence indicates that more than 90 % of infected individuals never develop active tuberculosis. This fact highlights the relevance of the immune response in tuberculosis control. Therefore, researchers assess the synthesis nitric oxide (NO), IFN-γ, and IL-10 in CD3+ICOS+ T cells from healthy individuals, household contacts and patients with active pulmonary tuberculosis (PTB). The study results show that the CD3+ICOS+ T cells obtained from PTB patients are the main producers of NO, IFN-γ, and IL-10. In addition, the results imply that NO is a modulator of ICOS expression of T cells from PTB patients.
Source : /www.ncbi.nlm.nih.gov      2015/8/16 13:04

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