Increased intra- and extracellular granzyme expression in patients with tuberculosis

Granzymes (gzms) are proteases mainly found in cytotoxic lymphocytes. While the role of gzms in target cell death has been widely characterized, considerable evidence points towards broader roles related to infectious and inflammatory responses. To investigate the expression of the gzms in TB, intracellular gzms A, B and K and extracellular levels of gzmA and B were measured among studied groups in Bangladesh. The results reveal enhanced intra- and extracellular expression of gzmA and B in patients with pulmonary TB, suggesting that gzms are part of the host response to tuberculosis.
Source : www.sciencedirect.com      2015/7/18 20:05

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