The fibroblast growth factor-2 arrests Mycobacterium avium sp. paratuberculosis growth and immunomodulates host response in macrophages

Mycobacterium avium (M. avium), a mycobacterial species related to M. tb, shares similarities with M. tb in many ways. In a study, using M. avium infection of macrophages as a model, researchers systematically studied the effect of fibroblast growth factor-2 (FGF-2) on M. avium infection of macrophages. The results indicate that macrophage-secreted FGF-2 upon M. avium infection could suppress M. avium proliferation through various ways including cytokine production, enhancement of phagocytosis as well as oxygen/nitrogen metabolism.
Source : www.sciencedirect.com      2015/7/11 11:24

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