Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development

Mycobacterium tuberculosis is encapsulated by a thick and robust cell wall.The segment of the cell wall is comprised of peptidoglycan, a layer that is required for survival and growth of the pathogen. Enzymes that catalyse biosynthesis of the peptidoglycan are essential and are therefore attractive targets for discovery of novel antibiotics. Researchers demonstrate that natural substrates can be successfully docked into the active sites of the GlmS and GlmU (peptidoglycan biosynthesis enzymes). It is therefore expected that the models and the data provided in the study will facilitate translational research to develop new drugs to treat TB.
Source : www.tuberculosisjournal.com      2015/6/27 08:29

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