The Sculpting of the Mycobacterium tuberculosis Genome by Host Cell–Derived Pressures

Mycobacterium tuberculosis (M.TB) is an incredibly successful pathogen with an extraordinary penetrance of its target host population. The ability to infect many yet cause disease in few is undoubtedly central to this success. This ability relies on sensing and responding to the changing environments encountered during the course of disease in the human host. In analyzing the response of M.TB to a broad range of intracellular pressures, it is clear that, despite genome downsizing, M.TB has retained an extraordinary flexibility in central carbon metabolism. Scientists believe that it is this metabolic plasticity, more than any of the virulence factors, that is the foundation for M. tuberculosis’s qualities of endurance.
Source :      2015/4/13 13:09

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